Recent advances in the research of broad-spectrum antiviral agents
10.16438/j.0513-4870.2019-0839
- VernacularTitle:广谱抗病毒药物研究进展
- Author:
Tian-guang HUANG
1
;
Lin SUN
1
;
Peng ZHAN
1
;
Xin-yong LIU
1
Author Information
1. Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
- Publication Type:Research Article
- Keywords:
broad-spectrum;
antiviral agent;
rug target;
privileged structure
- From:
Acta Pharmaceutica Sinica
2020;55(4):679-693
- CountryChina
- Language:Chinese
-
Abstract:
Viral infections have always threatened human health. Broad-spectrum antiviral agents (BSAs) can either target host proteins that are essential for viral replication, or act on multiple viruses or multiple genotypes of the same virus. More importantly, BSAs could reduce the possibility of drug resistance. From the perspective of medicinal chemistry, this review summarizes recent advances in the research of broad-spectrum antiviral drugs with privileged structures or targeting specific targets in the viral life cycle.
