Recent progress in inhibitors against hepatitis C virus
10.16438/j.0513-4870.2019-0786
- VernacularTitle:丙型肝炎病毒抑制剂研究进展
- Author:
Shu SONG
1
;
Ping GAO
1
;
Peng ZHAN
1
;
Xin-yong LIU
1
Author Information
1. Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
- Publication Type:Research Article
- Keywords:
hepatitis C virus;
antiviral drug;
rug target;
rug design;
small molecule inhibitor
- From:
Acta Pharmaceutica Sinica
2020;55(4):652-668
- CountryChina
- Language:Chinese
-
Abstract:
Hepatitis C virus (HCV) infection is one of the global public health issues. Approximately, 130-150 million individuals are chronically infected worldwide and a quarter of these patients are at increased risk of developing liver cirrhosis, hepatocellular carcinoma and even liver failure. A complete eradication of the virus is one of the most important treatment goals for antiviral research. From the point of view of medicinal chemistry, we summarize and discuss current endeavors towards the discovery and development of novel inhibitors with various scaffolds or distinct mechanisms of action.
