Advances in human cytomegalovirus inhibitors
10.16438/j.0513-4870.2019-0729
- VernacularTitle:人巨细胞病毒抑制剂研究进展
- Author:
Jing LI
1
;
Xin-yong LIU
1
;
Peng ZHAN
1
Author Information
1. Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
- Publication Type:Research Article
- Keywords:
human cytomegalovirus;
rug target;
replication cycle;
rug design
- From:
Acta Pharmaceutica Sinica
2020;55(4):585-596
- CountryChina
- Language:Chinese
-
Abstract:
At present, the anti-HCMV (human cytomegalovirus) drugs have some problems, such as moderate activity, poor bioavailability, which urge people to develop new anti-HCMV drugs. With the continuous study on the pathogenesis and biological characteristics of HCMV and the rapid development of new drug design strategies, new generation of anti-HCMV targets and drugs have been identified. This review selects the most representative research examples in recent years, and summarizes the new targets and research progress of anti-HCMV drugs from the perspective of medicinal chemistry.
