New progress in medicinal chemistry of anti-herpesviruses drug research
10.16438/j.0513-4870.2019-0723
- VernacularTitle:抗疱疹病毒药物化学研究新进展
- Author:
Wen-xiu WEI
1
;
Lan-lan JING
1
;
Xin-yong LIU
1
;
Peng ZHAN
1
Author Information
1. Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012,China
- Publication Type:Research Article
- Keywords:
herpesviruses;
rug target;
HHV;
anti-herpesviruses drug;
rug design
- From:
Acta Pharmaceutica Sinica
2020;55(4):575-584
- CountryChina
- Language:Chinese
-
Abstract:
At present, the most widely used anti-herpesviruses drugs are acyclovir (ACV) and its derivatives, but the emergence of herpesvirus resistance to these drugs forces people to continue to seek new anti-herpesviruses drugs. More and more new targets and inhibitors against herpesviruses have been discovered, one reason is the in-depth study of the biological characteristics and pathogenic mechanism of herpesviruses, and the other is the rapid development of new drug design and screening technology. Therefore, there are more options for the treatment of herpes infections. This review summarizes the representative achievements in the field of anti-herpesviruses drugs in recent years.
