Application progress of recombinant human endostatin in the treatment of head and neck cancer
10.12016/j.issn.2096-1456.2020.04.012
- Author:
LI Xiaodong
1
;
MENG Jian
1
Author Information
1. Stomatology, Xuzhou Central Hospital
- Publication Type:Review
- Keywords:
recombinant human endostatin;
head and neck cancer;
vascular normalization;
vascular endothelium;
targeted drug;
targeted therapy;
biotherapy;
chemotherapy synergy;
radiosensitive phase
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2020;28(4):267-272
- CountryChina
- Language:Chinese
-
Abstract:
The main treatment of head and neck cancer is comprehensive sequential treatment, but the 5-year overall survival rate is less than 50%. Strategies to further improve the curative effect of head and neck cancer are urgently needed in the clinic. Recombinant human vascular endostatin is an antiangiogenesis drug targeting vascular endothelial cells, which has a certain inhibitory effect on tumors. The treatment of malignant tumors by drugs alone is not significantly better than chemoradiation, but combined with radiotherapy and chemotherapy, it can increase the effect of radiotherapy and chemotherapy without drug resistance by changing the distribution of blood vessels, reducing oxygen and normalizing blood vessels. Head and neck tumor treatment has certain advantages. New tumor treatments are expected. The results of a literature review showed that the mechanism of action of recombinant human endostatin mainly includes regulating the matrix protein inside and outside the endothelial cells to influence neovascularization, acting on receptors related to the surface of endothelial cells, reversing abnormal neovascularization to achieve vascular normalization, inhibiting hypoxia inducible factor to improve the hypoxic status of the tumor area, and regulating the cell cycle to ensure the tumor cells are sensitive to radiation in the sensitive period, and vascular normalization can increase the effect of radiotherapy. This treatment has a good synergistic effect with radiotherapy and chemotherapy of head and neck tumors and has a good effect on advanced head and neck tumors.
- Full text:重组人血管内皮抑素在治疗头颈部恶性肿瘤中的应用进展.pdf
