Progress of research on association between schistosomiasis and single nucleotide polymorphisms
10.16250/j.32.1374.2018005
- VernacularTitle:单核苷酸多态性与血吸虫病相关性研究进展
- Author:
Si-Min DAI
1
;
Zhi-Qiang QIN
1
;
Chao LÜ
1
;
Jing XU
1
Author Information
1. National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention; WHO Collaborating Centre for Tropical Diseases; National Center for International Research on Tropical Diseases, Ministry of Science and Technology; Key Laboratory of Parasites and Vector Biology, National Health Commission of China, Shanghai 200025, China
- Publication Type:Journal Article
- Keywords:
Schistosomiasis;
Single nucleotide polymorphisms;
Genetic marker
- From:
Chinese Journal of Schistosomiasis Control
2018;30(6):702-704
- CountryChina
- Language:Chinese
-
Abstract:
Single nucleotide polymorphisms (SNP) has been regarded as a new genetic marker due to its rich dynamics and relatively stable heredity. SNP can express the relationship between genes and diseases to seek disease-linked genes particularly. A number of domestic and international studies have demonstrated that the formation of schistosomiasis egg granuloma is closely linked to HLA-Ⅱ related antigen. By detecting alleles loci of HLA-Ⅱ gene, researchers can identify the gene or haplotype that is associated with the susceptibility and progression of schistosomiasis. The detected candidate genes can serve useful therapeutic and preventative purposes by providing new technical methods to defeat schistosomiasis. In-depth study on SNP is beneficial to evaluate schistosomiasis inclination clinically, as well as to promote early diagnosis and preventive treatment.
