Research of hyperoxia-inducedlung injury related signaling pathways

VernacularTitle: 高氧肺损伤相关信号通路研究
Author: Mu-lin LIANG ¹ ; Cheng-jun LIU ¹ ; Hong-xing DANG ¹
Author Information

1. Department of PICU, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation base of Child development and Critical Disorders, Chongqing Key Laboratory Pediatrics, Chongqing 400014, China
Publication Type:Journal Article
Keywords: hyperoxia-induced lung injury; signal transduction; signaling pathways
From: Journal of Medical Postgraduates 2018;31(12):1333-1339
CountryChina
Language:Chinese
Abstract: Mammals exposured to high volume fractional oxygen (hyperoxygen) are prone to go under oxidative stress, and activating inflammatory cells in the lung produce cytotoxic reactive oxygen species directly or indirectly, activate complex signaling pathways and epigenetic factors, causing lung epithelial cells and endothelial cell damage and death. In the hyperoxia-induced lung injury-related signaling pathways, the current research includes MAPK pathway, P13K/Akt pathway, TGF-β related pathway, NF-κB pathway, Wnt pathway, Rho/Rock pathway, Notch pathway, Shh pathway, AngⅡ-P22phox-ROS pathway, Src pathway and so on. This review summarizes the research of these signaling pathways in hyperoxia-induced lung injury.