Progress of mechanism of 5-HT on bone metabolism

VernacularTitle: 5-HT对骨代谢作用机制的研究进展
Author: Mao-sheng BAI ¹ ; Kai-wen XUE ¹ ; Jian-ning ZHAO ¹
Author Information

1. Department of Orthopedics,Jinling Hospital, Medical School of Nanjing University/Nanjing General Hospital of Nanjing Military Region,PLA, Nanjing 210002, Jiangsu, China
Publication Type:Journal Article
Keywords: 5-hydroxytryptamine; tryptophanhydroxylase; 5-hydroxytryptamine receptor; bone metabolism
From: Journal of Medical Postgraduates 2018;31(11):1201-1206
CountryChina
Language:Chinese
Abstract: 5-HT as an important neurotransmitter which takes part in the development of many diseases, including bronchial asthma,schizophrenia and bone metabolism as reported in literatures in recent years. Central 5-HT can inhibit sympathetic excitations and promote bone formation through Tph2. Lrp5 can reduce the level of peripheral 5-HT and act on Tph1 to promote bone formation. Peripheral 5-HT blocks the association between transcription factor FOXO1 and CREB and inhibits bone formation. Peripheral 5-HT can also promote IL-6 expression and induce bone reabsorption. LP533401 as a Tph1 inhibitor could effectively reduce the level of peripheral 5-HT and induce bone formation as reported. In this paper, we try to summarize the effect of 5-HT on bone metabolism and its mechanism, and further using 5-HT to regulate bone quantity effectively.