A multicenter clinical study on the cause constituent ratio of chronic wet cough in children
- Author:
Qiang CHEN
1
Author Information
- Collective Name:Chronic Cough Collaboration Group of Respiration Group of Pediatrics Branch of Chinese Medical Association;Clinical Research Collaboration Group on the Cause Constituent Ratio of Chronic Wet Cough in Children
- Publication Type:Journal Article
- Keywords: cause; constituent ratio; chronic; wet cough; China; child
- From: Chinese Journal of Practical Pediatrics 2019;34(09):757-784
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To identify the causes of chronic wet cough in children in China and the constituent ratio of each cause so as to explore the most appropriate diagnosis procedure and treatment plan for children with chronic wet cough. METHODS: A prospective study was conducted between June 2015 and May 2018 in twenty-six hospitals in seventeen provinces,municipalities and autonomous regions;children with chronic wet cough were enrolled to identify the specific cause based on a questionnaire survey and then followed up in the next three months;all the data were collected and statistically analyzed to identify the constituent ratio of each cause. RESULTS: A total of 1505 cases were enrolled,of whom 1470 cases were qualified,the qualified rate being at 97.67%. The leading 4 causes were upper airway cough syndrome(UACS)with 584 cases(39.73%),asthma combined with UACS 241 cases(16.39%),asthma combined with infection 164 cases(11.16%),and PBB 151 cases(10.27%). In children aged<12 months,PBB ranked first(40.00%). There were 483 effective cases of chronic wet cough with multiple etiologies,accounting for 33.74% of the total cases;the main etiology among them was asthma combined with UACS,accounting for 16.39%. UACS is the primary cause of chronic wet cough in children in East China,North China and South China. Among other causes of chronic wet cough in children,the consituent ratio of each cause was different according to different ages and different regions,and even the same cause had different constituent ratio due to seasonal changes in the same region. CONCLUSION: The main causes of chronic wet cough in Chinese children are UACS,asthma with UACS,asthma with infection and PBB. Children at different ages have different cause constituent ratio. For children aged<12 months,PBB ranks first. The constituent ratio of each cause is different in different ages,regions and seasons.
