Effects of comprehensive intervention on the application of special-use-grade antibacterial agents and on bacterial resistance in oncology department
10.3969/j.issn.1006-0111.201908070
- VernacularTitle:综合干预对肿瘤科特殊使用级抗菌药物应用及细菌耐药性的影响
- Author:
Tao WANG
1
;
Baozhu ZHOU
1
;
Fang YU
2
;
Jie ZHU
1
;
Ying WANG
3
Author Information
1. Department of Pharmacy.
2. Department of Disease Control and Prevention.
3. Department of Economic Management.
- Keywords:
special-use-grade antibacterial agents;
bacterial resistance;
oncology department;
comprehensive intervention
- From:
Journal of Pharmaceutical Practice
2020;38(2):189-192
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the comprehensive intervention of special-use-grade antibacterial agents and their effects on bacterial resistance in oncology department, and analyze the effects of comprehensive intervention. Methods The medical records of 63 patients discharged from January to June 2017 were used as the control group, and the medical records of 61 patients discharged from January to June 2018 were used as the intervention group. The changes in the indicators of special-use-grade antibacterial agents before and after the intervention were compared. Results After comprehensive intervention, the pass rate of online consultation of special-use-grade antibacterial agents increased from 65.34% to 98.00%, with a statistical difference (P<0.05). DUI values of linezolid, amitraconam, carbophenazim and voriconazole decreased from more than 1 to less than 1. The usage rate of single use antibacterial agents was significantly increased, and the usage rate of combination of antibacterial agents was significantly decreased (P<0.05). Main pathogenic bacteria for escherichia coli, klebsiella pneumoniae, pseudomonas aeruginosa, staphylococcus aureus, white smooth candida yeast and candida, and their constituent ratio had no significant change. Except for klebsiella pneumoniae, the resistance rate of imipenem increased by 16.67%, while resistance rate of other pathogens is in a downward trend. Conclusion The comprehensive intervention makes the clinical application of special-use-grade antibacterial agents in oncology department increasingly reasonable.
