Liver Stiffness for Evaluating Change of Condition in Patients with Acute-on-chronic Liver Failure
- VernacularTitle:二维剪切波弹性成像肝硬度值评估慢加急性肝衰竭 患者病情变化
- Author:
Huan-yi GUO
1
;
Shi-cheng XU
1
;
Mei LIAO
1
;
Jie-yang JIN
1
;
Jie ZENG
1
;
Rong-qin ZHENG
1
Author Information
1. Department of Medical Ultrasonics；Guangdong Key Laboratory of Liver Disease Research，The Third Affiliated Hospital of Sun Yat-sen University，Guangzhou 510630，China
- Publication Type:Journal Article
- Keywords:
bilirubin；shear wave elastography；acute-on-chronic liver failure；ultrasonography
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2019;40(5):723-730
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】To study the correlation between hepatocellular jaundice and liver stiffness measurement and
reflect the changes in patients with acute-on-chronic liver failure（ACLF）.【Methods】Between January 2015 and March
2016，a total of 150 patients with ACLF-HBV infection were enrolled to collect clinical data，2D-SWE and biochemical
variables. According to data distribution，correlation of total bilirubin with LSM by 2D-SWE was assessed by Pearson
correlation analysis.【Results】One hundred and twenty-one patients were analyzed and divided into two groups：descended
TB group and elevated TB group. For descended TB group，LSM decreased 5.1（2.2～6.6）kPa. For elevated TB group，
LSM increased 6.2（1.2～12.8）kPa. A significant parallel correlation between TB and LSM value either the descended TB group or the elevated TB group. For descended TB group，accompanied with the decrease of LSM，patients reached
clinical improvement standard and their average hospitalization time was 30 ± 15 days. Six patients underwent liver trans⁃
plantation in the elevated TB group，and showed TB level higher than twenty ULN（the upper limit of normal），ac⁃
companied with increased LSM value. Histological characteristics of these patients showed submassive hepatic necrosis.
【Conclusion】The degree of hepatic necrosis aggravation in patients with ACLF，which results in the continuous increase
of TB and LSM，reflects the aggravation of patients′ condition；on the contrary，the decline in value of LSM reflects the
improvement of patients′ condition.
