The Effects of Open-Lung Strategy on Lung Injury Markers in Patients under General Anesthesia with Low-tidal-volume Ventilation
- VernacularTitle:小潮气量机械通气期间肺开放策略对肺损伤标志物的影响
- Author:
Hong LI
1
;
Wei WANG
1
;
Yao-jun LIAO
1
;
Zhi-nan ZHENG
1
;
Nan-rong ZHANG
1
;
San-qing JIN
1
Author Information
1. Department of Anesthesia，the Sixth Affiliated Hospital，Sun Yat-sen University，Guangzhou 510655，China
- Publication Type:Journal Article
- Keywords:
open-lung strategy, low-tidal-volume ventilation, lung epithelial injury markers, soluble , receptor for advanced glycation end products, Clara cell protein
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2020;41(2):281-287
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】To determine the effects of an open-lung strategy（OLS）comprising moderate positive end- expiratory pressure （PEEP） and intermittent recruitment manoeuvres（RMs） on plasma levels of lung epithelial injury markers［i.e. soluble receptor for advanced glycation end products（sRAGE）and Clara cell protein（CC16）］during low- tidal-volume ventilation for surgery.【Methods】One hundred patients who were undergoing laparoscopic colorectal cancer resection under low-tidal-volume ventilation were enrolled in this study. They were randomly assigned（1∶1）to the OLS group（using PEEP of 6~8 cmH2O and intermittent RM），or the NOLS group（without using PEEP and RM）. Blood samples were taken before anesthesia induction（T1），immediately after surgery（T2）and the postoperative day 3（T3）to measure the plasma concentrations of sRAGE and CC16. 【Results】 Significant differences were not observed in the concentrations of sRAGE and CC16 at T1，T2 and T3 between the two groups（all P > 0.05）. For all the enrolled patients， the concentrations of sRAGE at T2 and T3 were higher than that at T1，the concentration of sRAGE at T3 was higher than that at T2，and the concentration of CC16 at T3 was higher than that at T1 and T2（all P < 0.05）.【Conclusions】In patients under general anesthesia with low-tidal-volume ventilation，the using of an OLS comprising medium PEEP and intermittent RMs can not alter plasma levels of lung epithelial injury markers（sRAGE and CC16）in three days after surgery.
