Advance in the Monitoring and Treatment of Sepsis-Induced Immunosuppression
- VernacularTitle:脓毒症免疫抑制的监测和治疗进展
- Author:
Jian-feng WU
1
Author Information
1. Department of Critical Care Medicine，The First Affiliated Hospital，Sun Yat-sen University，Guangzhou 510080，China
- Publication Type:Journal Article
- Keywords:
sepsis, immunosuppression, immunotherapy
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2020;41(1):30-36
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is defined as a life- threatening organ dysfunction caused by a deregulated host response to infection and is the leading cause of mortality in intensive care units. Although the exact pathogenesis of sepsis remains unclear，immunosuppression is considered to play a key role. Sepsis-induced immunosuppression is characterized by a failure to eradicate the primary infection and by development of secondary nosocomial infections， resulting in a prolonged hospitalization and increased death rate in sepsis patients. Early recognition of immunosuppression and appropriate intervention will benefit these patients. This review helps clinicians identify patients with immunosuppression through high-risk population screening and biomarkers detection，and introduces immunostimulants that have been used in clinics and clinical trials.
