The Function and Regulatory Mechanism of TBK1 in Antiviral Innate Immunity
- VernacularTitle:TBK1 在抗病毒固有免疫中的作用及其调控机制
- Author:
Wei ZHAO
1
Author Information
1. Department of Immunology，School of Basic Medical Science，Shandong University，Jinan 250012，Shandong，China
- Publication Type:Journal Article
- Keywords:
TBK1, innate immunity, antiviral immunity
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2020;41(1):1-6
- CountryChina
- Language:Chinese
-
Abstract:
TANK- binding kinase 1（TBK1）acts as the hub of antiviral innate immune signal transduction. On the one hand，TBK1 could be activated by a variety of pattern recognition receptors（PRR）. On the other hand，as a critical kinase，activated TBK1 phosphorylates varieties of substrates，such as transcription factors interferon regulatory factor 3（IRF3）and IRF7 ，resulting in the initiation of antiviral innate immune responses. In this review ，we put emphasis on the TBK1 associated antiviral innate immune signaling ，as well as the regulation mechanisms of TBK1 expression and activation.
