Meta-analysis of the Therapeutic Efficacy of Sodium Hyaluronate Combined with Compound Betamethasone versus Sodium Hyaluronate in the Treatment of Knee Osteoarthritis
- VernacularTitle:玻璃酸钠联合复方倍他米松对比玻璃酸钠治疗膝关节骨性关节炎疗效的Meta分析
- Author:
Ping SONG
1
;
Xiaorong WANG
1
;
Yiye LI
1
;
Weiwei LIN
1
;
Xuefei ZHU
1
;
Zhibin MENG
1
Author Information
1. Dept. of Traumatology，the First Affiliated Hospital of Hai nan Medical College，Haikou 570102，China
- Publication Type:Journal Article
- Keywords:
Sodium hyaluronate;
Compound betamethasone;
Knee osteoarthritis;
Therapeutic efficacy;
Meta-analysis
- From:
China Pharmacy
2019;30(16):2274-2278
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE： To systematically evaluate therapeutic efficacy of sodium hyaluronate combined with Compound betamethasone versus sodium hyaluronate in the treatment of knee osteoarthritis （KOA）， and to provide evidence-based reference for clinical drug use. METHODS： Randomized controlled clinical trials （RCTs） about sodium hyaluronate combined with Compound betamethasone （observation group） versus sodium hyaluronate （control group） in the treatment of KOA were collected from Cochrane Library， PubMed， Embase， Web of Science， CNKI， Wanfang database and Baidu academics database， etc. By literature screening， data extraction and quality evaluation of included literatures with Jadad scale， Meta-analysis was carried out by using Rev Man 5.3 software. RESULTS： Totally 24 RCTs were included， involving 2 929 patients. Meta-analysis showed that total response rate [OR＝5.33， 95％CI（3.85， 7.38）， P＜0.000 01]， knee joint score of American Special Surgical Hospital [SMD＝1.63， 95％CI（1.32， 1.93）， P＜0.000 01]， knee function score [SMD＝1.22， 95％CI（0.84， 1.59）， P＜0.000 01] of the observation group were significantly higher than those of the control group； visual analogue score was significantly lower than that of control group [SMD＝－1.44， 95％CI（－1.76，－1.11）， P＜0.000 01]. CONCLUSIONS： In the treatment of KOA， therapeutic efficacy of sodium hyaluronate combined with Compound betamethasone is significantly better than sodium hyaluronate， and it can significantly improve knee function.
