Clinical effects of clomiphene citrate combined with low molecular weight heparin calcium in the treatment of patients with polycystic ovary syndrome infertility
- Author:
Ye LIU
;
Ting-ting FU
1
;
Cun-hua ZOU
1
;
Han-ying CHENG
1
;
Xiu-zhen GONG
;
Shu-ping ZHAO
1
Author Information
- Publication Type:Journal Article
- Keywords: clomiphene citrate; low molecular weight heparin calcium; endometrial receptivity; polycystic ovary syndrome; infertility
- From: Chinese Journal of Practical Gynecology and Obstetrics 2019;35(04):438-441
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To discuss the clinical effects of clomiphene citrate combined with low molecular weight heparin calcium in the treatment of patients with polycystic ovarian syndrome(PCOS)infertility. METHODS: A total of 105 patients with PCOS infertility who were admitted to the Outpatient Department of Women and Children's Hospital of Qingdao University from September 2016 to April 2018 were taken as research subjects.They were randomly divided into observation group(57 cases)and control group(48 cases).The control group received clomiphene citrate for ovulation treatment,the observation group was given clomiphene citrate combined with low molecular weight heparin calcium for ovulation treatment,and the endometrial receptivity changes,pregnancy rate and the incidence of adverse reactions of patients were compared between the two groups.RESULTS: In the observation group,the endometrial thickness,blood flow index(FI),endometrial spiral arterial blood flow resistance index(RI)and pulsatility index(PI)decreased,and the pregnancy rate was better than that in the control group;the difference was statistically significan(t P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).CONCLUSION: Clomiphene citrate combined with low molecular weight heparin calcium in the treatment of polycystic ovary syndrome infertility can improve the treatment efficiency,and is safe and reliable.It is worthy of clinical promotion.
