Research progress in protein-energy metabolism and intestinal mucosa immunization in kidney diseases
- Author:
Jia-wei HE
1
;
Xu-jie ZHOU
1
Author Information
- Publication Type:Journal Article
- Keywords: protein metabolism; immunometabolism; gut microbiome; kidney disease
- From: Chinese Journal of Practical Internal Medicine 2019;39(11):945-948
- CountryChina
- Language:Chinese
- Abstract: Immunometabolism, focusing on the changes in intracellular metabolic pathways in immune cells that alter their function, is one of the most important research fields in recent years. Researches on the metabolism of carbohydrates, lipids,and proteins of immune cells shed important light on a better understanding of the physiological and pathological mechanisms of several diseases. For example, innate and adaptive immunity have been recently confirmed to be involved in obesity, further increasing risk of type 2 diabetes, cardiovascular disease, cancer and neurodegenerative disease. Interactions between metabolic aberrations and chronic kidney diseases always lead to a vicious spiral in disease etiology and progression. Up to date, emerging evidence has also indicated a therapeutic role of immune-metabolism. In this perspective,we aim to discuss some of these novel findings, with a special focus on how protein metabolism shaping immune system and gut microbiome in kidney disease. We hope the readers find our account understandable, interesting and thought-provoking for their own research.
