Progress in study on the role of exosome-derived microRNA in diagnosis and treatment of diseases.
10.11817/j.issn.1672-7347.2015.11.018
- Author:
Hui TANG
1
;
Haishan WU
1
;
Yi YANG
1
;
Jingping ZHAO
1
;
Jindong CHEN
1
Author Information
1. Mental Health Institute of the Second Xiangya Hospital, Central South University; The China National Clinical Research Center for Mental Health Disorders; National Technology Institute of Psychiatry; Key Laboratory of Psychiatry and Mental Health of Hunan Province, Changsha 410011, China.
- Publication Type:Journal Article
- MeSH:
Apoptosis;
Biomarkers;
Cell Proliferation;
Exosomes;
genetics;
Humans;
Mental Disorders;
diagnosis;
therapy;
MicroRNAs;
genetics;
Neoplasms;
diagnosis;
therapy;
Nervous System Diseases;
diagnosis;
therapy
- From:
Journal of Central South University(Medical Sciences)
2015;40(11):1270-1275
- CountryChina
- Language:Chinese
-
Abstract:
Exosome is a kind of biological membrane structure at nanometer level. It is secreted by various cells in the body and widely distributed in most body fluids, such as saliva, blood, and milk. Biological active substances, including mRNAs, microRNAs, cytokines, and transcription factor, have been identified in the exosomes. MiRNAs are short and non-coding RNAs that modulate gene expression at the posttranscriptional level. MiRNAs extensively involves in henogenesis, cell proliferation and apoptosis. With various biological functions, exosome-derived miRNAs can not only be served as biomarkers to diagnose tumor, neurological diseases and mental disorders, but also possess potential as therapeutic targets.
