Research progress in mechanisms for drug-resistance and recurrence in bladder cancer.
10.11817/j.issn.1672-7347.2019.11.180353
- Author:
Xin GAO
1
;
Shufang ZHANG
2
Author Information
1. Central Laboratory, Affiliated Haikou Hospital of Xiangya School of Medicine, Central South University, Haikou 570208; Clinical Laboratory, First People's Hospital of Huaihua, Huaihua Hunan 418000, China.
2. Central Laboratory, Affiliated Haikou Hospital of Xiangya School of Medicine, Central South University, Haikou 570208, China.
- Publication Type:Journal Article
- MeSH:
Cell Line, Tumor;
Cisplatin;
Drug Resistance, Neoplasm;
Humans;
Neoplasm Recurrence, Local;
Urinary Bladder Neoplasms
- From:
Journal of Central South University(Medical Sciences)
2019;44(11):1287-1293
- CountryChina
- Language:Chinese
-
Abstract:
Bladder cancer is a common malignant tumor in the urinary system, and its drug-resistant recurrence has become a major problem in clinical treatment. At present, there is still a lack of molecular markers for effectively predicting bladder cancer resistance. The mechanisms for drug resistance in bladder cancer is very complicated. The common mechanisms of drug resistance include epigenetic modification, abnormal expression level, abnormal regulation of non-coding RNA, production of bladder cancer stem cells, increase of drug efflux and autophagy. The various drug resistance mechanisms of bladder cancer are not independent, but there is a certain relationship between them, which leads to the occurrence of drug resistance. Further study on the mechanisms for bladder cancer resistance is of great importance to overcome these problems.
