Sperm mitochondrial DNA and male infertility: An update.
- Author:
Gang-Qin LI
1
;
Ying HE
2
Author Information
1. Department of Urology, Xuyi Hospital of Traditional Chinese Medicine, Xuyi, Jiangsu 211700, China.
2. Department of Andrology, Jiangsu Provincial Hospital of Traditional Chinese Medicine, Nanjing, Jiangsu 210029, China.
- Publication Type:Journal Article
- Keywords:
male infertility;
mitochondrial DNA;
sperm
- MeSH:
DNA Damage;
DNA, Mitochondrial;
Humans;
Infertility, Male;
genetics;
Male;
Mitochondria;
Oxidative Stress;
Reactive Oxygen Species;
adverse effects;
Spermatozoa
- From:
National Journal of Andrology
2017;23(9):848-851
- CountryChina
- Language:Chinese
-
Abstract:
Sperm mitochondrial DNA (mtDNA) damage is closely related with male infertility. Lacking for the protection by histone and DNA-binding protein, sperm mtDNA is prone to the attack by reactive oxygen species (ROS) and, without an effective repair system of mtDNA, ROS-induced changes in mtDNA may damage the synthesis of mtDNA encoding proteins and affect the function of mitochondria, which may be an important genetic factor for male infertility. Related studies should focus on finding the causes of sperm mtDNA damage and its relationship with male infertility.
