Testosterone Undecanoate Pills improves insulin resistance in type-2 diabetes men with hypogonadism.
- Author:
Hong-Jie DI
1
;
Yao-Fu FAN
1
;
Hui-Feng ZHANG
1
;
Ke-Mian LIU
1
;
Chao LIU
1
Author Information
1. Department of Endocrinology, Jiangsu Provincial Hospital of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210028, China.
- Publication Type:Journal Article
- MeSH:
Androgens;
administration & dosage;
therapeutic use;
Blood Glucose;
analysis;
Body Mass Index;
Diabetes Mellitus, Type 2;
blood;
complications;
drug therapy;
Glycated Hemoglobin A;
analysis;
Humans;
Hypogonadism;
blood;
drug therapy;
Insulin Resistance;
Lipids;
blood;
Male;
Testosterone;
administration & dosage;
analogs & derivatives;
therapeutic use;
Waist Circumference
- From:
National Journal of Andrology
2017;23(6):517-521
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effects of Testosterone Undecanoate Pills (TUP) on insulin resistance (IR) in type-2 diabetes men with hypogonadism.
METHODS:We randomly divided 82 type-2 diabetes patients with hypogonadism into a treatment (n = 42) and a control group (n = 40), both maintaining their glucose- and lipid-reducing therapies, while the former treated orally with TUP in addition. After 6 months of medication, we compared the body mass index (BMI), waist circumference (WC), blood glucose level, HbA1c, lipid profile, IR index obtained by homeostatic model assessment (HOMA-IR), insulin sensitivity index (ISI), sex hormone levels, and sexual function scores between the two groups of patients.
RESULTS:Compared with the baseline, the patients in the treatment group showed significant decreases after medication in BMI (［26.71 ± 2.39］ vs ［25.15 ± 2.28］ kg/m2, P <0.05), WC (［89.96 ± 9.13］ vs ［85.03 ± 9.58］ cm, P <0.05), HbA1C (［7.73 ± 1.31］ vs ［7.01 ± 1.25］ %, P <0.05), and triglyeride (［1.97 ± 0.83］ vs ［1.41 ± 0.69］ mmol/L, P <0.05), a markedly elevated level of total testosterone (［7.16 ± 2.21］ vs ［14.22 ± 2.63］ nmol/L, P <0.05), and remarkable improvement in HOMA-IR (3.76 ± 1.18 vs 2.55 ± 1.03, P <0.05), ISI (96 ± 51 vs 138 ± 53, P <0.05) and total scores of the Aging Males' Symptoms (P <0.05). But no significant changes were observed in the scores of the International Index of Erectile Function (IIEF) after treatment (13.28 ± 6.38 vs 14.95 ± 6.08, P >0.05).
CONCLUSIONS:TUP can significantly improve insulin resistance in type-2 diabetes men with hypogonadism.
