Rhododendron Molle (Ericaceae): phytochemistry, pharmacology, and toxicology.
10.1016/S1875-5364(18)30073-6
- Author:
Yong-Qing CAI
1
;
Jian-Hui HU
2
;
Jie QIN
3
;
Tao SUN
4
;
Xiao-Li LI
5
,
6
Author Information
1. Department of Pharmacy, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China.
2. Student Brigade Ten Team, Second Military Medical University, Shanghai 200433, China.
3. Student Eleven Camp, Third Military Medical University, Chongqing 400038, China.
4. College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China. Electronic address: suntao513@gmail.com.
5. College of Pharmacy, Chongqing Medical University, Chongqing 400016, China; Chongqing Key Laboratory of Drug Metabolism, Chongqing 400016, China. Electronic address: plum181181@
6. com.
- Publication Type:Journal Article
- Keywords:
Pharmacology;
Phytochemistry;
Rhododendron molle;
Toxicology
- MeSH:
Animals;
Humans;
Medicine, Chinese Traditional;
Molecular Structure;
Phytotherapy;
Plant Extracts;
chemistry;
pharmacology;
therapeutic use;
toxicity;
Plants, Medicinal;
Rhododendron;
chemistry
- From:
Chinese Journal of Natural Medicines (English Ed.)
2018;16(6):401-410
- CountryChina
- Language:English
-
Abstract:
Rhododendron molle G. Don, belonging to the Ericaceae family, is a traditional Chinese medicinal plant with a wide spectrum of pharmacological effects. This paper aimed to review the phytochemistry, pharmacology and toxicology of R. molle, and to discuss the tendency of future investigations on this plant. A systematic review of literature about R. molle was carried out using resources including classic books about Chinese herbal medicine, and scientific data bases including CNKI, Pubmed, SciFinder, Scopus, and Web of Science. Over 67 compounds, including diterpenes, triterpenes, flavonoids, and lignans, had been extracted and identified from R. molle. The extracts/monomers isolated from the root, flower and fruits of this plant were used as effective agents for treating pains, inflammatory diseases, hypertension, and pest, etc. In addition, diterpenes, such as rhodojaponin III, were considered as the toxic agents associated with the toxicities of this plant. These findings will be significant for the discovery of new drugs from this plant and full utilization of R. molle.
