Two new C steroidal glycosides isolated from Cynanchum komarovii.
10.1016/S1875-5364(18)30098-0
- Author:
Dan ZHAO
1
;
Shan-Shan SU
2
;
Shao-Fei CHEN
1
;
Xiao-Jie LU
1
;
Gang CHEN
1
;
Yu-Bo WANG
3
;
Guang-Yue SU
4
,
5
;
Yue-Hu PEI
5
,
6
Author Information
1. Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
2. Testing Laboratory, Qinghai Entry Exit Inspection and Quarantine Bureau, Xining 810000, China.
3. Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China; School of Pharmacy, Jinzhou Medical University, Jinzhou 121001, China.
4. Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: suggyy@
5. com.
6. Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: peiyueh@vip.
- Publication Type:Journal Article
- Keywords:
C(21) steroidal glycosides;
Cynanchum komarovii;
Cytotoxic activity
- MeSH:
Cell Survival;
drug effects;
Cynanchum;
chemistry;
Drugs, Chinese Herbal;
chemistry;
isolation & purification;
pharmacology;
Glycosides;
chemistry;
isolation & purification;
pharmacology;
HL-60 Cells;
Humans;
Magnetic Resonance Spectroscopy;
Molecular Structure;
Steroids;
chemistry;
isolation & purification;
pharmacology
- From:
Chinese Journal of Natural Medicines (English Ed.)
2018;16(8):610-614
- CountryChina
- Language:English
-
Abstract:
The present study was designed to further investigate the C steroidal glycosides in Cynanchum plants. Two new steroidal glycosides based on a 13, 14:14, 15-disecopregnane-type aglycone, komaroside P (1) and komaroside Q (2), together with three known compounds (3-5) were isolated from the whole herbs of Cynanchum komarovii. The aglycones of compounds 1 and 2 were two new disecopregnane. Their structures were elucidated on the basis of 1D, 2D NMR spectroscopic data and acid hydrolysis. All the compounds (1-5) showed potent inhibitory activities against human leukemia cell lines (HL-60) with IC values ranging from 16.6 to 26.3 μmol·L, compared to the positive control 5-fluorouracil (6.4 μmol·L).
