Advances in the antitumor activities and mechanisms of action of steroidal saponins.
10.1016/S1875-5364(18)30113-4
- Author:
Ya-Zheng ZHAO
1
;
Yuan-Yuan ZHANG
1
;
Han HAN
1
;
Rui-Ping FAN
1
;
Yang HU
1
;
Liang ZHONG
1
;
Jun-Ping KOU
2
;
Bo-Yang YU
3
,
4
Author Information
1. Jiangsu Key Laboratory of TCM Evaluation and Translational Research, Department of Complex Prescription of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing 211198, China.
2. Jiangsu Key Laboratory of TCM Evaluation and Translational Research, Department of Complex Prescription of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing 211198, China. Electronic address: junpingkou@cpu.edu.cn.
3. Jiangsu Key Laboratory of TCM Evaluation and Translational Research, Department of Complex Prescription of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing 211198, China. Electronic address: boyangyu59@
4. com.
- Publication Type:Journal Article
- Keywords:
Mechanism;
Steroidal saponins;
Tumor
- MeSH:
Animals;
Antineoplastic Agents, Phytogenic;
chemistry;
pharmacology;
Apoptosis;
drug effects;
Cell Proliferation;
drug effects;
Humans;
Neoplasms;
drug therapy;
physiopathology;
Plant Extracts;
chemistry;
pharmacology;
Saponins;
chemistry;
pharmacology;
Steroids;
chemistry;
pharmacology
- From:
Chinese Journal of Natural Medicines (English Ed.)
2018;16(10):732-748
- CountryChina
- Language:English
-
Abstract:
The steroidal saponins are one of the saponin types that exist in an unbound state and have various pharmacological activities, such as anticancer, anti-inflammatory, antiviral, antibacterial and nerves-calming properties. Cancer is a growing health problem worldwide. Significant progress has been made to understand the antitumor effects of steroidal saponins in recent years. According to reported findings, steroidal saponins exert various antitumor activities, such as inhibiting proliferation, inducing apoptosis and autophagy, and regulating the tumor microenvironment, through multiple related signaling pathways. This article focuses on the advances in domestic and foreign studies on the antitumor activity and mechanism of actions of steroidal saponins in the last five years to provide a scientific basis and research ideas for further development and clinical application of steroidal saponins.
