Effect of an active fraction isolated from the leaf extract of Leptadenia reticulata on plasma glucose concentration and lipid profile in streptozotocin-induced diabetic rats.
10.1016/S1875-5364(14)60071-6
- Author:
Natarajan VENKATESAN
1
;
Arul Gnana Dhas ANTON SMITH
2
Author Information
1. Department of Pharmacy, Annamalai University, Annamalai Nagar - 608002, India. Electronic address: venkatcology@gmail.com.
2. Department of Pharmacy, Annamalai University, Annamalai Nagar - 608002, India.
- Publication Type:Journal Article
- Keywords:
Blood glucose;
Leptadenia reticulata;
Lipid profile
- MeSH:
Animals;
Apocynaceae;
Blood Glucose;
metabolism;
Cholesterol;
blood;
Cholesterol, HDL;
blood;
Diabetes Mellitus, Experimental;
blood;
drug therapy;
Hypoglycemic Agents;
pharmacology;
therapeutic use;
Lipids;
blood;
Male;
Phytotherapy;
Plant Extracts;
pharmacology;
therapeutic use;
Plant Leaves;
Rats, Wistar;
Triglycerides;
blood
- From:
Chinese Journal of Natural Medicines (English Ed.)
2014;12(6):455-460
- CountryChina
- Language:English
-
Abstract:
AIM:To evaluate the effect of an active fraction from Leptadenia reticulata leaves on serum glucose and lipid profile in normal and diabetic rats.
METHOD:Diabetes was induced by streptozotocin in Wistar rats. Petroleum ether, ethyl acetate, and ethanol extracts of Leptadenia reticulata leaves were administered orally at a dose of 200 mg·kg(-1), p.o. Metformin was used as standard anti diabetic drug (50 mg·kg(-1), p.o). The extract showing higher antidiabetic activity was subjected to column chromatography and led to the isolation of an active fraction, which was given trivial name Lr-1. Lr-1 (100 mg·kg(-1), p.o.) was studied for its hypoglycemic and hypolipidemic potential.
RESULTS:The ethanol extract was found to lower the FBG level significantly (P < 0.05) in diabetic rats. Lr-1 caused a significant (P < 0.05) reduction in FBG level, and additionally it caused reduction in cholesterol, triglyceride levels, and an improvement in the HDL level in diabetic rats.
CONCLUSION:Reduction in the FBG, cholesterol, triglyceride levels, and an improvement in the HDL by Lr-1 indicates that Lr-1 has antidiabetic activity, along with cardioprotective potential, and provides a scientific rationale for the use as an antidiabetic agent.
