Engineered mesenchymal stem cells as targeting therapeutic carriers in cancer therapy

VernacularTitle:间充质干细胞在肿瘤靶向递药系统中的应用
Author: Yuekui ZHAO ¹ ; Shanshan TANG ; Yanfeng ZHANG ; Li ZONG ; Liang JIN
Author Information

1. 中国药科大学药剂学教研室
Publication Type:Journal Article
Keywords: mesenchymal stem cells; targeting drug delivery; antitumor; application
From: Journal of China Pharmaceutical University 2016;47(2):134-139
CountryChina
Language:Chinese
Abstract: Mesenchymal stem cells(MSCs)were derived from the early development stage of mesoderm and ectoderm and considered as one of the important members of stem cells family. Besides that, MSCs can be isolated easily and don′t have a limitation of moral and ethical problems. Moreover, MSCs can be expanded in vitro which make it possible to use in industrial preparation. Moreover, MSCs possess low immunogenicity and has the ability to home to damaged tissues, tumors, and metastases. Therefore, MSCs possess a set of fairly unique properties which make them ideally suited for clinical applications. This review summarizes the main properties of MSCs and its new progress in drug delivery system in the field of cancer therapy as a basis of further utility of engineered MSCs in the design of targeting drug delivery system.