Progress of small molecule anti-tumor covalent drugs
10.11665/j.issn.1000-5048.20170101
- VernacularTitle:小分子抗肿瘤共价药物的研究进展
- Author:
Danfeng ZHANG
1
;
Yu JIAO
;
Yong LIU
;
Yanmin ZHANG
;
Zhimin ZHANG
;
Tao LU
Author Information
1. 中国药科大学理学院
- Publication Type:Journal Article
- Keywords:
covalent drugs;
anti-tumor;
development strategy;
progress
- From:
Journal of China Pharmaceutical University
2017;48(1):1-7
- CountryChina
- Language:Chinese
-
Abstract:
Covalent drugs are a type of inhibitors which exert their biological functions by irreversibly binding to the target through covalent bonds. With the marketing of kinase inhibitor covalent drugs against tumor, covalent drugs have regained the attention for drug discovery and have become a recent hotspot of anti-tumor drugs. In this paper, the action mechanisms, pharmacological advantages and the development strategies of modern covalent drugs are discussed and the recent research progress of anti-tumor covalent inhibitors is summarized, which provides a reference for the design of new anti-tumor covalent drugs.
