Retinal Ganglion Cell Layer Thicknesses and Visual Functions in Patients with Bilateral Temporal Optic Atrophy
10.3341/jkos.2020.61.1.92
- Author:
Bum Gi KIM
1
;
Jae Yong PARK
;
Won Hyuk OH
;
Jin CHOI
Author Information
1. Department of Ophthalmology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea. Sylvia8@hanmail.net
- Publication Type:Original Article
- Keywords:
Optic atrophy;
Retinal ganglion cell layer;
Visual acuity;
Visual disorder;
Visual field
- MeSH:
Diabetic Retinopathy;
Humans;
Optic Atrophy;
Retinal Ganglion Cells;
Retinaldehyde;
Tomography, Optical Coherence;
Vision Disorders;
Visual Acuity;
Visual Field Tests;
Visual Fields
- From:Journal of the Korean Ophthalmological Society
2020;61(1):92-100
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To investigate correlations between macular retinal ganglion cell (RGC) layer thickness and best-corrected visual acuity (BCVA) and visual field parameters in patients with bilateral temporal optic atrophy.METHODS: Thirty eyes of 15 patients with bilateral temporal optic atrophy and 30 eyes of 15 normal subjects that were age- and sex-matched were included in the study. We measured the thicknesses of the RGC layers of posterior poles using optical coherence tomography volume scanning. The RGC layer was divided into nine zones based on the Early Treatment of Diabetic Retinopathy Study baseline. Possible correlations of the RGC layer with the BCVA and visual field parameters were determined.RESULTS: The RGC layer thickness was significantly thinner in all patients compared to those in the control group (p = 0.001). The RGC layer thicknesses in the inner superior, inner temporal, inner inferior, and inner nasal areas were significantly correlated with the BCVA (r = −0.650, r = −0.626, r = −0.616, and r = −0.636, respectively; p = 0.000). The RGC layer thicknesses in the outer superior, outer temporal, outer inferior, and outer nasal areas were significantly correlated with the mean deviation of the visual field test (r = 0.470, r = 0.349, r = 0.496, and r = 0.469, respectively; p < 0.05).CONCLUSIONS: In patients with bilateral temporal optic atrophy, the RGC layer thickness in the medial region was correlated with the BCVA, and the RGC layer thickness in the lateral region was correlated with the mean deviation of the visual field test.
