Clinicopathological characteristics and prognosis analysis with Paget′s disease of the breast
10.3760/cma.j.issn.0253-3766.2018.07.008
- VernacularTitle: 乳腺派杰氏病的临床病理特征及预后
- Author:
Jie WANG
1
;
Weijie YU
2
;
Xin WANG
1
;
Xiang WANG
1
;
Yantao TIAN
3
Author Information
1. Department of Breast Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
2. Department of Breast Surgery, Affiliated Hospital of Chifeng University, Chifeng 024005, China
3. Pancreatic and Stomach Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
- Publication Type:Clinical Trail
- Keywords:
Paget′s disease, Mammary;
Pathology, Clinical;
Therapy;
Prognosis
- From:
Chinese Journal of Oncology
2018;40(7):523-527
- CountryChina
- Language:Chinese
-
Abstract:
Objective:The aim of this study was to explore the clinicopathologic characteristics and prognostic factors of Paget′s disease.
Methods:137 patients with Paget′s disease of the breast who were diagnosed in Cancer Hospital Chinese Academy of Medical Sciences between January 2007 and May 2016 were identified and included in the study, including 134 females and 3 males.
Results:The average age at onset of the disease was 51.8 years(range, 27-78 years). Among the 137 patients, 7 cases were Paget′s disease without any other underlying malignancy, who were alive during the follow-up period. The other 130 patients were diagnosed with Paget′s disease and underlying ductal carcinoma in situ (DCIS) or (and) with an invasive carcinoma. The positive expression rates of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER-2) were 29.2%(40/137), 38.0%(52/137)and 78.1%(107/137), respectively. The two-year and five-year overall survival were 99.0%, 96.0%, and disease-free survival of two-year and five-year were 97.6%, 92.8%, respectively for all 137 patients. On survival analysis, longer course of disease, HER-2 positivity, tumor stage(T1-T4), and axillary lymph node metastasis were significantly associated with overall survival.
Conclusions:Paget′s disease of the breast is a slowly progressive malignancy with good prognosis. A longer course of disease, HER-2 positivity, tumor stage, axillary lymph node metastasis and distant metastasis were significantly associated with poor prognosis.
