The impact of arousal on sleep-related deglutition in patients with obstructive sleep apnea hypopnea syndrome
10.3760/cma.j.issn.1673-0860.2018.06.005
- VernacularTitle: 阻塞性睡眠呼吸暂停低通气综合征患者微觉醒对睡眠时吞咽的影响
- Author:
Yanru LI
1
;
Xiu DING
1
;
Chunyan WANG
1
;
Demin HAN
1
Author Information
1. Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otorhinolaryngology Head and Neck Surgery(Capital Medical University), Ministry of Education, Beijing 100730, China
- Publication Type:Journal Article
- Keywords:
Sleep apnea, Obstructive;
Arousal;
Deglutition
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2018;53(6):419-423
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the sleep-related deglutition in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) and its correlation with sleep stage and cortical arousals.
Methods:From December 2015 to September 2017, simultaneous polysomnography and pharyngeal pressure monitoring were performed in 23 adult patients with OSAHS, Mann-Whitney U test were employed to analyze the following parameters: (1) the relationship between arousal and deglutition; (2) the effect of sleep stage on deglutition; (3) The relationship between the frequency of deglutition and the severity of OSAHS.
Results:The subjects in this study aged (43±12) years, and the mean apnea-hypopnea index (AHI) was (49.2±27.7) times/hour. A total of 1 382 deglutition were recorded during sleep, with a median of 9.2[5.8, 13.8]times/person. There was a positive correlation between deglutition frequency and AHI(r=0.570, P=0.005) and negatively correlated with oxygen saturation (r=-0.639, P=0.001). The majority of the deglutition (73.7%) occurred after the respiratory event and in association with respiratory arousal. Deglutition occurred more in Non-rapid eye movement sleep stage 1 (N1) than N2, N3 and REM sleep (Z=-3.680, P<0.001; Z=-2.746, P=0.006; Z=- 3.490, P<0.001).
Conclusions:The occurrence of deglutition in patients with OSAHS is associated with cortical arousals. Deglutition frequency increased with the severity of apnea and affected by sleep staging.
