Periodontitis is associated with rheumatoid arthritis: a study with longstanding rheumatoid arthritis patients in Korea.
- Author:
In Ah CHOI
1
;
Jin Hee KIM
;
Yong Mi KIM
;
Joo Youn LEE
;
Kyung Hwa KIM
;
Eun Young LEE
;
Eun Bong LEE
;
Yong Moo LEE
;
Yeong Wook SONG
Author Information
- Publication Type:Original Article
- Keywords: Periodontitis; Arthritis, rheumatoid
- MeSH: Antibodies; Arthritis, Rheumatoid*; Blood Sedimentation; Cross-Sectional Studies; Hemorrhage; HLA-DRB1 Chains; Humans; Inflammation; Korea*; Leukocytes; Periodontal Index; Periodontitis*; Prevalence
- From:The Korean Journal of Internal Medicine 2016;31(5):977-986
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: A cross-sectional study was undertaken to investigate the association between severity of periodontitis and clinical manifestation of rheumatoid arthritis (RA). METHODS: Two hundred sixty-four RA patients and 88 age- and sex-matched controls underwent dental exam. Additionally, clinical manifestations including disease activity and anti-citrullinated protein antibodies were evaluated in RA patients. RESULTS: The prevalence of moderate or severe periodontitis was higher in RA patients compared to controls (63.6% vs 34.1%, p < 0.001). In markers of periodontal inflammation, bleeding on probing was correlated with disease activity score 28 (r = 0.128, p = 0.041), RA disease duration (r = 0.211, p = 0.001), erythrocyte sedimentation rate (ESR; r = 0.141, p = 0.023), anti-cyclic citrullinated peptide antibody (r = 0.183, p = 0.009), and anti-citrullinated α-enolase peptide-1 antibody (r = 0.143, p = 0.025). Gingival index was correlated with RA duration (r = 0.262, p < 0.001), ESR (r = 0.162, p = 0.009), anti-cyclic citrullinated peptide antibody (r = 0.203, p = 0.004) and anti-citrullinated α-enolase peptide-1 antibody (r = 0.225, p < 0.001). Periodontal structural damage represented by probing pocket depth and clinical attachment level were less in RA patients with human leukocyte antigen (HLA)-DRB1 shared epitope compared than those without shared epitope (p = 0.005 and p =0.006, respectively). CONCLUSIONS: The prevalence of moderate or severe periodontitis was increased in RA patients compared to controls. Periodontal inflammation was correlated with RA disease duration, ESR, and anti-citrullinated protein antibodies. Periodontal structural damage was less in RA patients with HLA-DRB1 shared epitope.
