Advances in the research of effects of regulation of cell autophagy on wound healing
10.3760/cma.j.issn.1009-2587.2017.10.009
- VernacularTitle: 细胞自噬调控在创面修复中的作用研究进展
- Author:
Min LI
1
;
Dewu LIU
Author Information
1. Department of Gynecology and Obstetrics, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China
- Publication Type:Journal Article
- Keywords:
Autophagy;
Wound healing;
Fibrosis;
Molecular regulation
- From:
Chinese Journal of Burns
2017;33(10):625-628
- CountryChina
- Language:Chinese
-
Abstract:
As one of the self-protection mechanism, autophagy widely exists in eukaryotic cells. It plays an important role in maintaining cells survival, update, material recycling, and tissue homeostasis. A series of researches discovered that autophagy played dual function in fibrotic diseases. The induction of autophagy can promote the degradation of collagen on one hand, on the other hand, the regulation of autophagy through microRNA, transforming growth factor β, and other factors can promote the occurrence of fibrosis. In wound healing, autophagy may participate in the pathophysiological processes of inflammation, reepithlialization, and wound remodeling. The regulation of cell autophagy may become an effective way and the new target for treatment of wound and pathological scar.
