Structure and function of human norovirus nonstructural proteins
10.3760/cma.j.issn.1003-9279.2017.05.022
- VernacularTitle: 人诺如病毒非结构蛋白的结构和功能
- Author:
Yue YUAN
1
;
Xin YUAN
2
;
Yan XIN
1
;
Lili PANG
3
Author Information
1. Department of Immunology, Basic School of Medical Science, Inner Mongolia Medical University, Hohhot 010110, China
2. Department of Bioengineering, School of Biological Engineering, Chongqing University, Chongqing, China
3. Key Labortory of Medical Virology, Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
- Publication Type:Review
- Keywords:
Human norovirus;
Calicivirus;
Nonstructural protein;
Viral replication
- From:
Chinese Journal of Experimental and Clinical Virology
2017;31(5):479-483
- CountryChina
- Language:Chinese
-
Abstract:
Norovirus (NoV), a single stranded RNA virus, is the major causative agent of the global acute gastroenteritis in humans, and it has drawn more and more attention. Because of the lack of appropriate animal models and in vitro cell culture models, people have studied and understood more about the epidemiology and genetic variation of human viruses. The functional characteristics of the viral encoded protein and the pathogenesis of virus infection are poorly understood. In this paper, we summarize the progress in studies on characteristics of non-structural protein of norovirus, and hope that with the recent breakthrough in human cell culture model of human norovirus, it can be used as a tool for further research on the function of human norovirus non-structural protein.
