Changes of peripheral follicular helper T cell subsets in HIV infected patients
10.3760/cma.j.issn.1003-9279.2017.05.003
- VernacularTitle: HIV感染者外周血滤泡辅助性T细胞亚群变化特征研究
- Author:
Shuang ZHAO
1
;
Weiwei CHEN
2
;
Min ZHAO
2
Author Information
1. Peking University No. 302 Clinical Medical School, Beijing 100039, China
2. Treatment and Research Center for Infectious Diseases, the No. 302 Military Hospital, Beijing, 100039, China
- Publication Type:Journal Article
- Keywords:
HIV infection;
Follicular helper T cells;
Tfh17;
Tfh2;
Tfh1
- From:
Chinese Journal of Experimental and Clinical Virology
2017;31(5):392-396
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the changes of the frequencies of follicular helper T (Tfh) cell subsets in peripheral blood of HIV-1 infected patients and its relevance to the disease severity.
Methods:Twenty untreated HIV+ patients, 20 HAART-suppressed patients and 15 health controllers are enrolled in this study. The frequencies of Tfh and its subsets were examined by flow cytometry.
Results:The frequency of Tfh17 subset in peripheral blood decreased significantly in untreated HIV-1+ patients as compared with those of healthy controls and HAART-suppressed patients (P<0.05). In addition, the frequency of this subset were positively correlated with CD4+ T cell counts in both untreated and treated HIV+ patients, and were inversely correlated with viral load and plasma-immunoglobulin in untreated HIV+ patients. The frequency of Tfh2 subset, however, were inversely correlated with CD4+ T cell counts and positively correlated with viral load and plasma-immunoglobulin in untreated HIV+ patients. The frequency of Tfh1 subset in peripheral blood increased significantly in untreated and treated HIV-1+ patients as compared with those of healthy controls (P<0.05) and were inversely correlated with viral load and plasma-immunoglobulin in untreated HIV+ patients and positively correlated with CD4+ T cell counts.
Conclusions:The abnormal distribution of Tfh subests may play a role in the progression of HIV infection and its characteristic immune activation.
