Survival analysis of 104 cases of osteosarcoma with lung metastases
10.3760/cma.j.issn.0253-3766.2017.04.005
- VernacularTitle: 104例骨肉瘤肺转移患者的预后及其影响因素
- Author:
Juan REN
1
;
Yefeng XU
1
;
Tanghong KUANG
1
;
Jing CHEN
1
;
Yunxia LIU
1
Author Information
1. Department of Oncology, Hangzhou Third People's Hospital, Hangzhou 310009, China
- Publication Type:Clinical Trail
- Keywords:
Osteosarcoma;
Neoplasm metastasis;
Lung neoplasms;
Prognosis
- From:
Chinese Journal of Oncology
2017;39(4):263-268
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the prognosis of osteosarcoma patients with lung metastases and its correlated factors.
Methods:The clinical data of 104 osteosarcoma patients with lung metastasis from April 2007 to September 2015 were retrospectively analyzed. Univariate analysis was performed using Kaplan-Meier and Log rank test. Multivariate Cox regression was applied to analyze independent prognostic factor for patient survival.
Results:The one-year, two-year and five-year survival rates of the 104 osteosarcoma patients with lung pulmonary metastasis were 93.3%, 61.5% and 11.5%, respectively, and the median survival time was 33 months. The univariate analysis revealed that number of lung metastases, objective response of first-line chemotherapy and therapeutic methods for lung metastases were significant prognostic factors for patient survival, whereas gender, age, time to lung metastasis and time to other metastasis were not (P>0.05). The multivariate analysis indicated that number of lung metastases, objective response of first-line chemotherapy and therapeutic methods for lung metastases were independent significant prognostic factors for patient survival.
Conclusions:The prognosis of osteosarcoma patients with advanced lung metastases and active treatment is better. Surgery and adjuvant chemotherapy could effectively prolong survival time for osteosarcoma patients with pulmonary metastasis.
