Palonosetron combined with dexamethasone prevents nasopharyngeal carcinoma radiotherapy cisplatin-induced nausea and vomiting
10.3760/cma.j.issn.1008-6706.2018.17.006
- VernacularTitle: 帕洛诺司琼联合地塞米松预防鼻咽癌放疗中顺铂增敏所致恶心呕吐的临床分析
- Author:
Bin LONG
1
;
Jiali SU
1
;
Limin LIU
1
;
Xinhui YANG
1
;
Xiaoyan SHI
2
;
Jun LONG
2
;
Shuliang LI
1
;
Guanghua ZHOU
1
Author Information
1. Department of Oncology, the 163rd Hospital of PLA(the Second Affiliated Hospital of Hunan Normal University), Changsha, Hunan 410003 China
2. Special Clinic, the 163rd Hospital of PLA(the Second Affiliated Hospital of Hunan Normal University), Changsha, Hunan 410003 China
- Publication Type:Journal Article
- Keywords:
Palonosetron;
Dexamethasone;
Nausea;
Vomiting;
Nasopharyngeal neoplasms
- From:
Chinese Journal of Primary Medicine and Pharmacy
2018;25(17):2197-2202
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the efficacy and adverse reactions of palonosetron and dexamethasone in preventing cisplatin-induced nausea and vomiting.
Methods:From September 2015 to August 2017, a total of 217 nasopharyngeal carcinoma patients in the 163rd Hospital of PLA were randomly divided into two groups according to the digital table.The control group (n=108) was given palonosetron when used cisplatin treatment, the study group(n=109) was given palonosetron combined with dexamethasone.The clinical efficacy and adverse reactions in the two groups were observed.
Results:After treatment of 1-6 weeks, the incidence rates of headache, dizziness and fatigue in the study group were 7.2%, 2.9% and 3.4% respectively, which were significantly lower than those in the control group(12.7%, 6.0% and 6.3%), the differences between the two groups were statistically significant(χ2=10.902, 7.412, 6.207, all P<0.05). The prevention rate of nausea and vomiting in the control group was 75.5%, which in the study group was 80.9%, and at delay period, the prevention rate of nausea and vomiting in the control group was 85.5%, which in the study group was 91.0%, the differences between the two groups were statistically significant(χ2=5.615, 9.442, all P<0.05).
Conclusion:Palonosetron and dexamethasone are effective in the treatment of nasopharyngeal carcinoma with cisplatin-induced nausea and vomiting, and can reduce the side effects of palonosetron.
