Clinical efficacy of transurethral resection of bladder tumor combined with gemcitabine intravesical instillation in the treatment of superficial bladder cancer
10.3760/cma.j.issn.1008-6706.2018.17.002
- VernacularTitle: 经尿道膀胱肿瘤电切术联合吉西他滨膀胱灌注治疗浅表性膀胱癌的临床效果分析
- Author:
Lei WANG
1
;
Changhua HU
;
Yu ZHAO
;
Xiaoquan HU
Author Information
1. Department of Urinary Surgery, the Seventh Hospital of Ningbo, Ningbo, Zhejiang 315202, China
- Publication Type:Journal Article
- Keywords:
Urinary bladder neoplasms;
Urethra bladder tumor electrocision;
Gemcitabine;
Chemotherapy, cancer, regional perfusion;
Superficial bladder cancer
- From:
Chinese Journal of Primary Medicine and Pharmacy
2018;25(17):2180-2183
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of transurethral resection of bladder tumor (TURBt) combined with gemcitabine intravesical instillation in the treatment of superficial bladder cancer.
Methods:From May 2011 to January 2016, 112 patients with superficial bladder cancer were treated in the Seventh Hospital of Ningbo.According to the digital table, the patients were randomly divided into two groups: A group was treated by TURBt, and B group was treated by TURBt combined with gemcitabine.The postoperative complications, postoperative recurrence and quality of life were compared between the two groups.
Results:The operation time, indwelling catheter time and hospitalization time between the two groups had no statistically significant differences (all P>0.05). The postoperative complications of the two groups were frequent urination, dysuria and hematuria.The incidence rate of complications of A group was 39.29%, which was significantly higher than that of B group (χ2=36.597, P<0.05). The recurrence rate of B group was significantly better than that of A group (χ2=8.617, P<0.05). After treatment, the quality of life of the two groups was significantly improved compared with that before treatment, and compared with that of A group, the psychology, physiology, independence, social environment, quality of life scores of B group increased more significantly (t=29.217, 25.446, 19.517, 24.339, 36.001, all P<0.05).
Conclusion:Transurethral resection of bladder tumor combined with gemcitabine intravesical instillation in the treatment of superficial bladder cancer can ensure the treatment effect, at the same time, it can effectively reduce the postoperative complications and the emergence of various risk, reduce postoperative recurrence and improve the quality of life of patients, it has great significance and is worthy of promotion.
