Effects of butylphthalide combined with clopidogrel on the blood viscosity and parameters of transcranial Doppler in patients with cerebral infarction
10.3760/cma.j.issn.1008-6706.2018.11.009
- VernacularTitle: 丁苯酞联合氯吡格雷对早期脑梗死患者血液黏稠度和经颅多普勒检测参数的影响
- Author:
Xudong LU
1
;
Yuhua JIN
;
Xiaoxiang YU
;
Heping SHEN
;
Yanping WANG
Author Information
1. Department of Neurology, the Second Hospital of Jiaxing, Jiaxing, Zhejiang314000, China
- Publication Type:Journal Article
- Keywords:
Brain Infarction;
Clopidogrel;
Ultrasonography, doppler;
Hemorheology;
Diphthalein
- From:
Chinese Journal of Primary Medicine and Pharmacy
2018;25(11):1391-1394
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effects of the combination of butylphthalide and clopidogrel on the blood viscosity and parameters of transcranial Doppler in patients with cerebral infarction.
Methods:Ninety patients with cerebral infarction were selected, and they were divided into control group and observation group according to the digital table, with 45 cases in each group.The control group was orally given clopidogrel, the observation group was given clopidogrel combined with butylphthalide.The clinical curative effect, blood viscosity changes and transcranial Doppler changes were compared between the two groups.
Results:The total effective rate of the observation group was 93.33%, which was significantly higher than 73.33% of the control group (χ2=5.67, P<0.05). After treatment, the HSV and PSV of the two groups were lower than those before treatment(t=4.34, 4.56, 7.89, 7.23, all P<0.05), and the decrease of HSV and PSV in the observation group was more significant than those in the control group after treatment(t=6.55, 6.67, all P<0.05). Compared with those before treatment, the Vm of ACA and MCA in the two groups after treatment significantly increased(t=4.34, 4.90, 7.33, 6.92, all P<0.05), the PI of ACA and MCA significantly decreased(t=4.77, 4.66, 7.12, 7.29, all P<0.05), and the above indicators in the observation group after treatment improved more significantly compared with those in the control group(t=6.31, 5.50, 6.54, 6.28, all P<0.05).
Conclusion:The effect of the early combination of butylphthalide and clopidogrel in the treatment of patients with cerebral infarction is significant, and it can effectively improve the change of blood viscosity.
