Overview of Staphylococcus aureus mobile genetic elements and horizontal gene transfer of antimicrobial resistance genes
10.3760/cma.j.issn.0253-9624.2018.10.020
- VernacularTitle: 金黄色葡萄球菌中可移动遗传元件与耐药传播机制研究进展
- Author:
Wei WANG
1
;
Fengqin LI
Author Information
1. Key Lab of Food Safety Risk Assessment, Ministry of Health, China National Center for Food Safety Risk Assessment, Beijing 100021, China
- Publication Type:Review
- Keywords:
Staphylococcus aureus;
Drug resistance;
Horizontal gene transfer;
Mobile genetic elements
- From:
Chinese Journal of Preventive Medicine
2018;52(10):1067-1071
- CountryChina
- Language:Chinese
-
Abstract:
The mechanism of antimicrobial resistance transmission mediated by mobile genetic elements (MGEs) in Staphylococcus aureus is highly complicated, leading a significant challenge for controlling the spread of the resistant Staphylococcus aureus strains. Based on the latest literature acquired in this work, we have overviewed the transmission mechanism of antimicrobial resistance encoding MGEs. It is notably that there are a number of MGEs, which may encode different antimicrobial resistance determinants and possess specific transmission mechanism. In spite of this specificity of the strains to their host (human or animal), some Staphylococcus aureus strains can be transmitted from animals to humans or vice versa. This ability of cross staphylococci transfer is an additional means to acquire new genetic material encoded by MGE. It was suggested in this review that study on transmission mechanism of MGEs mediated antimicrobial resistance genes could provide important biological information of their spreading and effectively help prevent and control of the resistant strains and/or resistance genes among human, animals and ecologies.
