Toll-like receptors-mediated innate immune responses in HBV infection
10.3760/cma.j.issn.0254-5101.2018.08.013
- VernacularTitle: Toll样受体介导的固有免疫应答在HBV感染中的研究进展
- Author:
Liping CHEN
1
;
Jun HUANG
;
Jilin CHENG
Author Information
1. Shanghai Public Health Clinical Center Affiliated to Fudan University, Shanghai 201508, China
- Publication Type:Review
- Keywords:
Toll-like receptors (TLRs);
Hepatitis B virus (HBV);
Innate immunity
- From:
Chinese Journal of Microbiology and Immunology
2018;38(8):635-640
- CountryChina
- Language:Chinese
-
Abstract:
Hepatitis B virus (HBV) infection is still a major health problem worldwide, but the immunological mechanisms by which HBV causes chronic persistent infection remains controversial. HBV has evolved a series of strategies to interfere TLRs-mediated innate immunity in response to the host immune system and the dysfunction of TLRs is an important cause of persistent virus infection. The innate immune system is activated by pathogens recognition receptors (PRRs) that recognize specific pathogen associated molecular? patterns (PAMPs). Toll-like receptors (TLRs) are important PRRs and play a vital role in mediating innate immune responses to HBV, which is associated with the early clearance of HBV and the subsequent activation of specific immune responses. This review focused on the interplay between HBV and TLRs-mediated innate immune responses as well as research findings about immune therapeutic strategies established based on TLRs.
