Advances in research on non-structural protein 3 of dengue virus

VernacularTitle: 登革病毒非结构蛋白3(NS3)研究进展
Author: Lili LI ¹ ; Yuhua LI
Author Information

1. Division of Arbovirus Vaccine, Institute for Biological Product Control, National Institutes for Food and Drug Control, Beijing 102629, China
Publication Type:Review
Keywords: Dengue virus (DENV); Non-structural protein (NS3); Antiviral
From: Chinese Journal of Microbiology and Immunology 2018;38(7):549-555
CountryChina
Language:Chinese
Abstract: Dengue virus (DENV) is one of the most significant mosquito-borne viral pathogens that spread in the tropical and subtropical areas causing severe diseases in humans such as dengue fever (DF), dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). DENV RNA genome encodes three structural proteins and seven non-structural proteins. The non-structural protein 3 (NS3) contains two main functional domains: serine protease and RNA helicase. As a serine protease, NS3 together with host cell proteases can directly hydrolyze the ploy-protein that is translated from the viral genome into functional proteins. Functioning as a RNA helicase, it is closely related to the replication and transcriptional translation of the viral genome RNA. In this paper, the structure and functions of DENV NS3 and the research progress in related antiviral drugs were reviewed systematically.