Recent basic and genetic research progress of type 2 diabetes
10.3760/cma.j.issn.1000-6699.2018.07.015
- VernacularTitle: 2型糖尿病基础与遗传研究的进展
- Author:
Bin GU
1
;
Weiqiong GU
;
Jiqiu WANG
Author Information
1. Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
- Publication Type:Review
- Keywords:
Diabetes mellitus, type 2;
Obesity;
β
-Cell de-differentiation;
Insulin resistance;
Genetic variantion
- From:
Chinese Journal of Endocrinology and Metabolism
2018;34(7):605-609
- CountryChina
- Language:Chinese
-
Abstract:
In the past two years, a line of basic and genetic findings have been produced in the field of type 2 diabetes. Some evidence has suggested that mature β cell under long-term metabolic stress could de-differentiate into pre-endocrine cells and re-differentiate into α and PP endocrine cells. Several key factors were reported with genetic modified animal models in the past two years. A novel adipokine, Asprosin was found to control insulin resistance and food intake in both humans and mice. Additionally, researchers reported that gut microbiota was associated with the development of type 2 diabetes, and a few bacteria or certain enterotype could be valuable in the prediction of prevention and clinical intervention for diabetes. The genetic composition for missing heritability of type 2 diabetes and obesity was revealed with the next-generation sequencing strategy. Importantly, scientists at home and abroad made a significant progress in the field during the past few years, which should be reviewed here. (Chin J Endocrinol Metab, 2018, 34: 605-609)
