Research progress of the structure and function of untranslated regions of enterovirus 71 genome
10.3760/cma.j.issn.1003-9279.2018.05.022
- VernacularTitle: 肠道病毒71型非编码区结构与功能研究进展
- Author:
Zhen DONG
1
;
Hongling WEN
Author Information
1. Department of Microbiological Laboratory Technology, School of Public Health, Shandong University; Key Laboratory for prevention and control of infections deseases(Key Laborutory of the "13th five-year" University of Shandong), Jinan 250012, China
- Publication Type:Review
- Keywords:
Enterovirus 71;
5′Untranslated regions;
3′Untranslated regions
- From:
Chinese Journal of Experimental and Clinical Virology
2018;32(5):553-556
- CountryChina
- Language:Chinese
-
Abstract:
Enterovirus 71 (EV71) is one of the important pathogens of hand, foot and mouth disease (HFMD) in infants and young children. It is also a very important and common virus after poliovirus which is associated with severe acute neurological disease. Mutations or spatial structure changes in untranslated regions (UTRs) may affect the ability of the virus to translate and replicate, as well as the affinity of the virus for cellular tissue, and even lead to changes in virulence. At present, the pathogenic mechanism of EV71 is still unknown, and the study of untranslated regions is an indispensable part. Here we briefly review the development of the study of basic structure and function of EV71 untranslated regions in recent years.
