Advances in the research of relationship between brown or beige fat and hypermetabolism after severe burn
10.3760/cma.j.issn.1009-2587.2018.03.014
- VernacularTitle: 棕色或米色脂肪与严重烧伤后超高代谢的关系研究进展
- Author:
Meng ZHANG
1
;
Yan LIU
;
Xiong ZHANG
Author Information
1. Department of Burns and Plastic Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China
- Publication Type:Review
- Keywords:
Burns;
Adipose tissue, brown;
Hormones;
Beige adipose tissue;
Hypermetabolism
- From:
Chinese Journal of Burns
2018;34(3):178-182
- CountryChina
- Language:Chinese
-
Abstract:
Hypermetabolism is one of the remarkable characteristics of burn injury. Prolonged hypermetabolism causes insufficient energy supply, which leads to delayed wound healing, immune system dysfunction, increased infection rate, and multi-organ failure. In recent years, it is concerned that the activation of brown or beige adipose tissue may be related to hypermetabolism in severe burn patients. Brown or beige adipose tissue could be regulated by stress hormones and some cytokines which increase and persist in high level for several months after severe burn. This paper reviews the current knowledge of brown or beige adipocytes developmental lineages, molecular regulation mechanism, and regulation of brown or beige adipocytes activation after severe burn.
