Autophagy and hypoxic ischemic myocardial damage after severe burn
10.3760/cma.j.issn.1009-2587.2018.01.002
- VernacularTitle: 自噬与严重烧伤后心肌缺血缺氧损害
- Author:
Yuesheng HUANG
1
Author Information
1. Institute of Burn Research, the First Affiliated Hospital, State Key Laboratory of Trauma, Burns and Combined Injury, Army Medical University (the Third Military Medical University), Chongqing 400038, China
- Publication Type:Journal Article
- Keywords:
Burns;
Anoxia;
Myocardium;
Autophagy
- From:
Chinese Journal of Burns
2018;34(1):3-7
- CountryChina
- Language:Chinese
-
Abstract:
It is an important clinical subject to illuminate the mechanisms of myocardial damage in the early stage post severe burn in prevention against and treatment of burn shock, which may offer a targeted " dynamic support" in the treatment of severe burn patients. In recent years, the role of autophagy in hypoxic myocardial injury has attracted much attention. Autophagy is a physiological phenomenon on intracellular digestion process of long-life proteins and the aging and damaged organelles through lysosomal system, and it is essential for maintaining the homeostasis of cells. Severe hypoxia/ischemia causes lysosome dysfunction, insufficient fusion between autophagosome and lysosome, accumulation of autophagosomes, and damaged autophagy flux, thus leading to cell dysfunction and cell death. To study the roles of autophagy and explore the potential signals in autophagy modulation will provide a new therapeutic target for alleviating cardiac dysfunction following severe burn.
