Effectiveness of continuous positive airway pressure ventilation in improving genioglossus electromyography in patients with moderate to severe obstructive sleep apnea
10.3760/cma.j.issn.1673-0860.2019.08.005
- VernacularTitle: 持续气道正压通气治疗对纠正中-重度阻塞性睡眠呼吸暂停患者颏舌肌肌电过高活性反应的评估
- Author:
Yingqian ZHOU
1
;
Di ZHAO
2
;
Guoping YIN
1
;
Jingjing LI
1
;
Xin CAO
1
;
Yuhuan ZHANG
1
;
Jingying YE
1
Author Information
1. Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing 102218, China
2. Department of Otorhinolaryngology Head and Neck Surgery, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China
- Publication Type:Journal Article
- Keywords:
Sleep apnea, obstructive;
Continuous positive airway pressure;
Genioglossus;
Intraoral electrode
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2019;54(8):584-590
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the changes of genioglossus electromyography (GGEMG) with and without continuous positive airway pressure (CPAP) ventilation in moderate to severe obstructive sleep apnea (OSA) patients.
Methods:Each of subjects, including male snorers and non-snorers, underwent polysomnography (PSG) with synchronous GGEMG recording with intra-oral bipolar silver ball electrodes at the Sleep Center of Beijing Tsinghua Changgung Hospital from August 2016 to Sepember 2017. Manual CPAP pressure titration and with GGEMG were performed in patients diagnosed moderate to severe OSA. T-test was used to compare the changes of GGEMG in OSA group (n=12, AHI (65.90+23.67) events/h) and control group (n=6, AHI(2.30+1.93) events/h) before and after CPAP treatment.
Results:Variables of GGEMG (including tonic, peak and phasic GGEMG) were higher in OSA group than in control group during both wakefulness and non rapid eye movement(NREM) sleep. However, with CPAP treatment, the GGEMG variables were significantly decreased in OSA group during NREM sleep(tonic GGEMG: 1.23%±0.73% vs. 2.54%±1.12%, t=4.024, P=0.002; peak GGEMG: 12.37%±13.19% vs. 26.98%±15.52%, t=2.795, P=0.017; phasic GGEMG: 3.81%±2.47% vs. 8.82%±3.84%, t=5.113, P<0.001).
Conclusions:CPAP treatment can eliminate respiratory events and maintain airway patency. It is helpful to normalize the excessive GGEMG response in OSA patients during sleep, which has therapeutic significance to alleviate and prevent genioglossal neuromuscular lesions.
