Lower respiratory tract of infection patients with coal worker's pneumoconiosis on isolation characteristics and drug resistance in HACEK bacteria
10.3760/cma.j.issn.1001-9391.2019.07.013
- VernacularTitle: 煤工尘肺下呼吸道感染患者HACEK菌群分离特点及耐药特性
- Author:
Yongxi SUN
1
;
Guihua SUN
2
;
Peiyue LIU
1
Author Information
1. Central Hospital of Zaozhuang Mining Group, Zaozhuang 277800, China
2. Xuecheng Linshan Middle School, Zaozhuang 277800, China
- Publication Type:Journal Article
- Keywords:
Coal worker'
s pneumoconiosis;
Lower respiratory tract;
Bacterial infections;
Resistance
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2019;37(7):535-538
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To summarize the isolation characteristics and drug resistance of HACEK bacteria in lower respiratory tract infection of coal worker's pneumoconiosis.
Methods:From 2016 to 2018, K-B method and MIC method were used to test the susceptibility of 10 commonly used antimicrobial agents to isolated 46 strains of HACEK bacteria, and the drug resistance of lactamase and non-enzyme producing haemophilus was compared.
Results:Haemophilus influenza (Hi) accounted for 71.74% (33/46) of the HACEK bacteria in the lower respiratory tract infection patients of coal workers' pneumoconiosis in our hospital, Haemophilus parainfluenzae (HPi) accounted for 23.91% (11/46) , which corroded one strain of Eikenella and one strain of actinomycetes. HACEK bacteria were isolated most in winter and spring, and less in summer and autumn. Cefuroxime, ceftriaxone, amoxicillin/clavulanic acid and levofloxacin have good antimicrobial activity against HACEK bacteria. The sensitivity of non-enzyme-producing strains Tetracycline (TE) , Compound trimethoprim (SXT) , Azithromycin (AZI) and Ampicillin (AMP) was stronger than that of enzyme-producing strains (P<0.05) .
Conclusion:Hi is the main HACEK bacteria isolated from patients with lower respiratory tract infection of coal worker's pneumoconiosis, followed by Hpi. The enzyme-producing strains of these bacteria are resistant to AMP, SXT and AZI to some extent. These drugs should not be the first choice for treatment.
