Progress in research on neurotoxicity of HIV-1 Nef protein
10.3760/cma.j.issn.1003-9279.2019.06.023
- VernacularTitle: HIV-1 Nef蛋白神经毒性研究进展
- Author:
Xiaoyu SHAN
1
;
Li ZHAO
Author Information
1. Department of Laboratory Science of Sanitary Microbiology, School of Public Health, Shandong University, Key Laboratory of Infectious Disease Prevention and Control, Key Laboratory of the 13th Five-Year University of Shandong Province, Jinan 250012, China
- Publication Type:Review
- Keywords:
Human immunodeficiency virus-1;
Nef protein;
Blood-brain barrier;
Neurotoxicity;
Astrocyte
- From:
Chinese Journal of Experimental and Clinical Virology
2019;33(6):667-670
- CountryChina
- Language:Chinese
-
Abstract:
Human immunodeficiency virus-1(HIV-1)is the causative agent of acquired immunodeficiency syndrome(AIDS), which can invade the central nervous system and cause a series of neurological disorders such as HIV-associated neurocognitive disorders(HAND). Nef protein is one of the early proteins of HIV-1 virus, it is found that the neurotoxicity of HIV-1 mutant lacking nef gene is less neurotoxic than that of wild strain with nef gene, indicating that Nef protein plays an important role in HIV-1 neuropathogenicity.In this paper, neurotoxicity and mechanism of Nef are reviewed from three aspects, including the effects of Nef on the blood-brain barrier permeability and the direct and indirect damage to neurons.
