Mechanism and research status of hemoperfusion in endotoxemia treatment
10.3760/cma.j.issn.1673-4181.2019.05.015
- VernacularTitle: 血液灌流治疗内毒素血症机理及研究进展
- Author:
Yichen LI
1
;
Juanjuan LIU
;
Hongxing GUO
;
Tao LI
Author Information
1. Ministry of Health Artificial Cell Engineering Research Center, Tianjin Key Laboratory of External Life Support for Severe Diseases, Tianjin Third Central Hospital, Tianjin 300170, China; Tianjin Key Laboratory of Hemoperfusion Technology Enterprises, Tianjin Zibo High-Tech Co., Ltd., Tianjin 300170, China
- Publication Type:Review
- Keywords:
Hemoperfusion;
Endotoxemia;
Asorption mechanism
- From:
International Journal of Biomedical Engineering
2019;42(5):441-445
- CountryChina
- Language:Chinese
-
Abstract:
Endotoxemia is a pathophysiological manifestation caused by the release of large amounts of endotoxin from bacteria in the blood or in the lesion. It can cause multiple organ failure, irreversible shock, and even death. The mortality rate of endotoxemiaIt is high. Bacterial endotoxin is the main cause of endotoxemia. At present, there is no safe and effective drug to treat endotoxemia in clinic. Research shows that blood purification can effectively reduce endotoxin level in the blood, then achieve the goal of treatment of endotoxemia. In this paper, the pathogenesis of endotoxemia, the development of hemoperfusion therapy technology, the mechanism and research status of endotoxin adsorption by different hemoperfusion resin were discussed, and the performance and safety requirements of hemoperfusion adsorbent materials for endotoxemia treatment were studied, so as to provide theoretical support for the synthesis of new hemoperfusion adsorption materials for the treatment of endotoxemia.
