Effect of anti-adhesion products on the healing of abdominal muscle
10.3871/j.1004-7220.2016.05.396
- VernacularTitle:各种防粘连产品对腹壁肌肉愈合的影响
- Author:
Fang YUAN
1
;
Long-xiang LIN
2
;
Quan-rong GAO
1
;
Hui-hui ZHANG
1
;
Ling QIN
3
;
Yu-long SUN
1
Author Information
1. Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences
2. Basic Medical College, Inner Mongolia Medical University
3. Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences;Orthopedic Laboratory, School of Medicine, The Chinese University of Hong Kong
- Publication Type:Journal Article
- Keywords:
Anti-adhesion products;
Muscle healing;
Biomechanics;
Histology
- From:
Journal of Medical Biomechanics
2016;31(5):E396-E400
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of commonly used anti-adhesion products on the healing of abdominal muscles, and to provide guidance for surgeons to use anti-adhesion products in their clinical practice. Methods Adult SD rats were used. Except the sham group, surgical traumas were created on the serosal layer of the cecum and the underlying muscles of the abdominal wall. The wounds were covered without (Adhesion group) or with anti-adhesion products. Fourteen days after the surgery, the mechanical properties and histology of abdominal muscles were investigated to evaluate the healing of injured muscles. Results The ultimate tensile force and stiffness of the healing abdominal muscles in the groups of Polylactic acid membrane and Medical polyethylene glycol berberis lye were the same as those of normal muscles (P>0.05). The ultimate tensile force of the healing muscle in the groups of Chitosan gel and Seprafilm was significantly smaller than that of normal muscles (P<0.05). But their stiffness did not show any significant differences (P>0.05). The significant losses of mechanical properties of the healing muscles occurred in the Adhesion and Medical sodium hyaluronate gel group (P<0.05). HE staining indicated that more capillaries were found in Medical sodium hyaluronate gel, Polylactic acid membrane and Medical polyethylene glycol berberis lye group. The wound in Medical sodium hyaluronate gel group had less fibroblasts and fewer inflammatory cells, while the inflammatory cells were fully infiltrated with dense fibers in the other product groups. Conclusions Polylactic acid membrane and Medical polyethylene glycol berberis lye can promote abdominal muscle healing and are superior to Medical sodium hyaluronate gel, Chitosan gel and Seprefilm.
